Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1-(4-Fluorophenyl)ethanone oxime | HCID 9497 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 131735869 | HCID 131735869 | 69.6% |
Reaction Steps
A mixture of 1-(4-fluorophenyl)ethanone oxime (8.00 g) and caesium carbonate (20.4 g) in acetonitrile was stirred at 20° C. for 30 minutes. Then ethyl bromoacetate (12.2 g) and potassium iodide (8.7 g) were added thereto and the mixture was stirred at 82° C. for 3 hours. Then the reaction mixture was filtered. The solvent was removed from the filtrate under reduced pressure. Purification by column chromatography gave ethyl({[1-(4-fluorophenyl)ethylidene]amino}oxy)acetate (8.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09375009B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-625bf3f749aa4ef681da9b52d5463b51 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
