Water → HCID 87158546, compound

Participants

Reaction Steps

1-[4-(Azidomethyl)-3-bromophenyl]-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidine (0.634 g) was dissolved in tetrahydrofuran (10 ml), to the solution was added a 1 M toluene solution (1.37 ml) of trimethylphosphine, and stirred for 10 minutes. To the reaction solution, water (0.09 ml) was added and stirred overnight at room temperature. The volatile compound was distilled off under reduced pressure to obtain almost pure 1-{2-bromo-4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl}methanamine (0.520 g).

Provenance & Evidence