Sodium Carbonate → HCID 87158388, compound

Participants

Reaction Steps

To a dichloromethane (200 ml) solution of 2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)pyrrolidin-1-yl]pyridine (3.4 g), an aqueous solution (100 ml) of sodium carbonate (1.2 g) was added. Under ice cooling, a dichloromethane solution of bromine (1.4 g) was added dropwise. Upon the completion of the dropwise addition, the stirring was continued for 1 hour at 0° C. The dichloromethane layer was separated and dried over magnesium sulfate. The solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography to obtain 3-bromo-2-methyl-6-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]pyridine (3.3 g).

Provenance & Evidence