Phthalimide → HCID 87158988, compound

Participants

Reaction Steps

{2-({2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol (Reference document: WO 2010/043315) (2.20 g), phthalimide (0.72 g) and triphenylphosphine (1.40 g) were dissolved in tetrahydrofuran (50 ml), and to the solution was added diethyl azodicarboxylate (40% toluene solution, 2.43 ml) at room temperature. After stirring the reaction solution for 3 hours, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to obtain the target compound (2.35 g).

Provenance & Evidence