Hydrazine hydrate (1:1) → 1-{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanamine

Participants

Reaction Conditions

Reaction Steps

2-({2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione (2.35 g) was added to ethanol (50 ml), followed by addition of hydrazine hydrate (0.37 ml) at room temperature. The reaction mixture was heated at 80° C. for 6 hours. The solvent was distilled off under reduced pressure, and then t-butyl methyl ether was added. The undissolved solids were removed by filtration, and the target compound was (1.71 g) obtained as a crude product after concentration under reduced pressure.

Provenance & Evidence