HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 87158550, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)-pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinate | HCID 87158454 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 87158550 | HCID 87158550 | 94.1% |
Reaction Steps
Methyl 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoro-methyl)nicotinate (1.21 g), sodium hydroxide (0.26 g) and water (5 ml) were added to ethanol (40 ml) and stirred at room temperature for 1 day. The solvent was distilled off under reduced pressure, diluted hydrochloric acid and t-butyl methyl ether were added and then extracted. The target compound (1.11 g) was obtained by concentration under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09375000B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-7ad7b739e0a6400f9b5b6ff95fcc2d71 |
| Source note | uspto-grants-2016_06 |