Trityl chloride → HCID 90046661, compound

Participants

Reaction Steps

Trityl chloride (˜3.45 g, ˜12.5 mmol) was slowly added into N-ethylethlenediamine (˜1.1 g, ˜12.5 mmol) DCM (methylene chloride) solution with stirring. After the reaction mixture was stirred at room temperature overnight (˜23 hours), HPLC indicated that the reaction was complete. After Biotage silica gel chromatography was performed (EtOAc/MeOH), Compound 2 was obtained as a white solid (˜3.5 g, ˜85% isolated yield), and the product was confirmed by proton NMR.

Provenance & Evidence