反应详情

温度

40 °C

Of the compound from Example 11, 266 mg (0.45 mmol) were introduced in 6 ml of methanol/water 1:1 and admixed with potassium cyanate (110 mg, 1.36 mmol) at RT. The mixture was heated at 40° C. for 90 min. Following complete reaction, the mixture was cooled to RT and purified completely by preparative HPLC (Method 10). Drying in an HV gave 232 mg (84% of theory) of the title compound.

1. customreaction
2. temperaturethe mixture was cooled to RT
3. custompurified completely by preparative HPLC (Method 10)
4. customDrying in an HV