反应详情

温度

40 °C

Of the compound from Example 12, 180 mg (0.31 mmol) were introduced in 3 ml of methanol/water 1:1 and admixed with potassium cyanate (75 mg, 0.92 mmol) at RT. The mixture was heated at 40° C. for 90 min. The methanol was removed on a rotary evaporator and the aqueous residue was diluted with 20 ml of water. The precipitated solid was isolated by filtration, washed with a little water and dried in an HV. This gave 146 mg (76% of theory) of the title compound.

1. customThe methanol was removed on a rotary evaporator
2. additionthe aqueous residue was diluted with 20 ml of water
3. customThe precipitated solid was isolated by filtration
4. washwashed with a little water
5. customdried in an HV