反应详情

温度

15 °C

To the solution of 6-methoxy-7-methylquinoline (4.28 g, 24.6 mmol) in 50 mL of concentrated H2SO4 was added N-bromosuccinimide (4.41 g, 14.6 mmol) at 15° C., and the reaction was stirred at 15° C. for 3.5 hours. The reaction mixture was poured into ice-water (600 mL). The aqueous mixture was adjusted with a 50% KOH solution to pH ˜10, and then extracted with DCM (3×). The combined extract was dried with sodium sulfate. Concentration under reduced pressure gave 5-bromo-6-methoxy-7-methylquinoline. LCMS-ESI+ (m/z): 252.1, 254.1 (M+H)+.

1. extractionextracted with DCM (3×)
2. extractionThe combined extract
3. dry with materialwas dried with sodium sulfate
4. concentrationConcentration under reduced pressure