3,3,3-Trifluoro-1-phenylpropan-1-amine → HCID 59536817, compound

HRID 220703Notes

Reaction equation

HRID 220703 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C@H:14]([OH:19])[C:15]([F:18])([F:17])[F:16])[C:11](=[O:20])[N:10]([CH2:21][C:22](NC(C3C=CC=CC=3C)CCO)=[O:23])[N:9]=2)=[CH:4][CH:3]=1.[F:36][C:37]([F:48])([F:47])[CH2:38][CH:39]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[NH2:40]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C@H:14]([OH:19])[C:15]([F:17])([F:16])[F:18])[C:11](=[O:20])[N:10]([CH2:21][C:22]([NH:40][CH:39]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH2:38][C:37]([F:47])([F:48])[F:36])=[O:23])[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 178957523,3,3-Trifluoro-1-phenylpropan-1-amineHCID 59536857HCID 59536857, compound

Product 1

HCID 59536817HCID 59536817, compound

Procedure

In the same way as for the compound from Example 86, 50 mg (0.14 mmol) of the compound from Example 8A and 28 mg (0.15 mmol) of 3,3,3-trifluoro-1-phenylpropan-1-amine were reacted. This gave 44 mg (59% of theory) of the target compound.

Sources & evidence

ORD record
ord-67523bdafdca4271bc28b9425d38bf67
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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