HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2207057Generated: November 2, 2026
Water → 4-(2-Fluoro-4-nitrophenyl)morpholine
https://huagongshe.com/reaction/2207057
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(2-Fluoro-4-nitrophenyl)morpholine | HCID 2905489 | 94.2% |
Reaction Steps
3,4-difluoro nitrobenzene (100 gr) is slowly added to a mixture of morpholine (76.6 gr), triethylamine (23 ml) and in presence of acetonitrile solvent (115 ml) at 40-50° C. Reaction mass is heated for 6 hrs at reflux temperature, cooled to 25-30° C. Then water (600 ml) is added slowly to the reaction mass and then cooled to 0-5° C. The reaction mixture is stirred for 1 hr. The solid is filtered to give 134 gr of 3-fluoro-4-morpholinyl nitrobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09376407B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-3f9442bbedaa49c7a228f2be931bd244 |
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| Source note | uspto-grants-2016_06 |
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