HCID 59536908, compound → HCID 59536851, compound

Participants

Reaction Steps

A solution of 118 mg (0.20 mmol) of the compound from Example 143 in 20 ml of methanol was hydrogenated by means of a continuous-flow hydrogenation apparatus (H-Cube, Thales Nano, Budapest, Model HC-2-SS), equipped with a 5% Pt/C catalyst cartridge, at 45° C. with a flow rate of 1 ml/min under standard pressure. The methanol was removed on a rotary evaporator and the residue was purified by preparative HPLC [Method 10]. This gave 31 mg (26% of theory) of the title compound.

Provenance & Evidence