Hydrochloric Acid → HCID 59536789, compound

Participants

Reaction Steps

A solution of 230 mg (0.37 mmol) of the compound from Example 145 and 54 mg (0.44 mmol) of DMAP in 5 ml of pyridine was admixed dropwise with 155 μl (0.92 mmol) of trifluoromethanoic anhydride and the resulting mixture was stirred at RT overnight. Subsequently 2 ml of 1N hydrochloric acid were added and the volatile components were removed on a rotary evaporator. The residue was dissolved in a little DMSO and purified by preparative HPLC [Method 10]. The product-containing fraction was freed from the solvents on a rotary evaporator and the residue was dried in an HV. This gave 168 mg (75% of theory) of the title compound.

Provenance & Evidence