HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3-aminohexan-1-ol → (S)-methyl 1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)-1H-imidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3-aminohexan-1-ol | HCID 11062353 | — |
| Reactant | methyl 1-(4-((2-amino-4-(mesitylenesulfonyloxy)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)-1H-imidazole-5-carboxylate | HCID 117992731 | — |
| Product | (S)-methyl 1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)-1H-imidazole-5-carboxylate | HCID 117992589 | 69% |
Reaction Steps
The sub-title compound was synthesized by the method of example 1 step (viii) from the product of step (i) (90 mg) and (s)-3-aminohexan-1-ol (56 mg). The sub-title compound (53 mg) was obtained as a colourless oil; LC-MS: m/z 483.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376398B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-37f9f93df18343f08134ac25f7d482d9 |
| Source note | uspto-grants-2016_06 |