Potassium ethanethioate → HCID 131735876, compound

Participants

Reaction Steps

(2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((tert-butoxycarbonyl)amino)propyl methanesulfonate (1.0 g, 2.15 mmol) and potassium ethanethioate (0.736 g, 6.45 mmol) were combined in DMF (5 ml). The reaction was stirred at room temperature for 5 hours under a N2 atmosphere. The reaction was diluted with 30% EtOAc in hexane, washed with water, then brine, dried over Na2SO4, filtered and concentrated. The compound was purified by column chromatography to yield S-((2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((tert-butoxycarbonyl)amino)propyl) ethanethioate. 1H NMR (500 MHz, CDCl3): δ 7.84 (s, 2H); 7.79 (s, 1H); 4.91 (s, 1H); 4.51 (s, 1H); 4.21 (s, 1H); 2.40 (s, 3H); 1.38 (s, 9H); 1.19 (d, J=6.9 Hz, 3H).

Provenance & Evidence