Acetic Acid → HCID 178494789, compound

Participants

Reaction Steps

A mixture of 2-tert-butyl-4-(2-methoxy-ethyl)-6-piperazin-1-yl-pyrimidine (500 mg, 1.796 mmol), trans-[4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (433 mg, 1.796 mmol) and AcOH (108 mg, 1.796 mmol) in DCE (30 ml) was stirred at room temperature for 10 min. Sodium triacetoxyhydroborate (571 mg, 2.69 mmol) was added. After 4 h, water was added. The aqueous layer was extracted with ethyl acetate (3×5 mL). The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the yellow title compound (900 mg, 1.680 mmol, 94% yield) which was used next step without purification.

Provenance & Evidence