HCID 178494789, compound → HCID 178494787, compound

HRID 2207121Notes

Reaction equation

C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([CH2:28][CH2:29][O:30][CH3:31])[N:25]=[C:24]([C:32]([CH3:35])([CH3:34])[CH3:33])[N:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C>Cl.CO>[C:32]([C:24]1[N:23]=[C:22]([N:19]2[CH2:20][CH2:21][N:16]([CH2:15][CH2:14][C@H:11]3[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]3)[CH2:17][CH2:18]2)[CH:27]=[C:26]([CH2:28][CH2:29][O:30][CH3:31])[N:25]=1)([CH3:35])([CH3:33])[CH3:34]

Participants

Conditions

Temperature: 25 °C

Procedure

Trans-[4-(2-{4-[2-tert-Butyl-6-(2-methoxy-ethyl)-pyrimidin-4-yl]-piperazin-1-yl}-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (900 mg, 1.680 mmol) was dissolved in 4 M HCl/MeOH (25 ml). The resulting solution was stirred at about 25° C. for about 16 h. The solvent was removed under reduced pressure to provide the title compound (690 mg, 1.539 mmol, 92% yield) as a colorless solid, which was used in the next step without further purification.

Workup

customThe solvent was removed under reduced pressure

Sources & evidence

ORD record: ord-7ae65880d45e4cd8ab4eb4076157e1e8
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376396B2

Reaction notes

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