Acetyl chloride → HCID 178494788, compound

Participants

Reaction Steps

A mixture of acetyl chloride (181 mg, 2.308 mmol), trans-4-(2-{4-[2-tert-Butyl-6-(2-methoxy-ethyl)-pyrimidin-4-yl]-piperazin-1-yl}-ethyl)-cyclohexylamine (690 mg, 1.539 mmol) and triethylamine (778 mg, 7.69 mmol) in DCM (15 ml) was stirred at room temperature for about 3 h. The solution was concentrated to dryness. The residue was transferred neat onto a 50×250 mm silica gel column and eluted with 5% MeOH/CH2Cl2. Fractions were collected and the solvent removed under reduced pressure to provide the title compound (468 mg, 1.040 mmol, 67.6% yield) as a white powder.

Provenance & Evidence