Boron tribromide → HCID 86725457, compound

Participants

Reaction Steps

To the solution of 2-tert-Butyl-4-(2-methoxy-ethyl)-6-piperazin-1-yl-pyrimidine (2.78 g, 9.99 mmol) in DCM (150 mL) was added BBr3 (3.75 g, 14.98 mmol) at 0° C. Then the mixture was stirred overnight at room temperature. The mixture was quenched with saturated aqueous NaHCO3 solution. The organic phase was separated out and dried over Na2SO4, filtered and concentrated. The crude title compound was used in the next step without any further purification.

Provenance & Evidence