HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2207147Generated: October 30, 2026
Crotonaldehyde → 3,4-dimethoxy-N-[(E)-5-oxopent-3-enyl]-N-phenyl-benzamide
https://huagongshe.com/reaction/2207147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Crotonaldehyde | HCID 447466 | — |
| Reactant | HCID 118557960 | HCID 118557960 | — |
| Catalyst | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,4-dimethoxy-N-[(E)-5-oxopent-3-enyl]-N-phenyl-benzamide | HCID 118557837 | 97% |
Reaction Steps
Crotonaldehyde (0.5 mL, 3 equiv) was added to a solution of compound 34 (608 mg, 1.95 mmol) in degassed CH2Cl2 (17 mL). Hoveyda-Grubbs' 2nd (31 mg, 2.5% mol) was added and the reaction mixture was heated to 40° C. under Ar atmosphere overnight. The reaction mixture was filtered over Celite and the filtrate was concentrated to dryness. The residue was purified by column chromatography on SiO2 (Petroleum ether/EtOAc=2:3) to afford the title compound 35 as white solid (Yield 644 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09376387B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-195c16f0539b450585eca6accd085c17 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
