Crotonaldehyde → HCID 118557992, compound

HRID 2207152Notes

Reaction equation

HRID 2207152 reaction equation
[CH2:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:14][CH3:15])[CH:10]=2)[C:5]1=[O:16])[CH:2]=[CH2:3].[CH:17](=[O:21])/C=C/C>>[CH3:15][O:14][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[C:5](=[O:16])[N:4]([CH2:1]/[CH:2]=[CH:3]/[CH:17]=[O:21])[CH2:13][CH2:12]2

Participants

3

Reactant 2

HCID 447466CrotonaldehydeHCID 59961793HCID 59961793, compound

Product 1

HCID 118557992HCID 118557992, compound

Procedure

The title compound 44 is prepared according to the procedure reported in step C of Example 8 with amide 43 (222.4 mg, 1.03 mmol) and crotonaldehyde (4.12 mmol, 4 equiv) as reactants. Brown solid. (Yield 242.5 mg, 96%).

Sources & evidence

ORD record
ord-188d428fcd424c438e0a58dc2e99eefe
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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