HCID 118557992, compound → HCID 118557821, compound

HRID 2207154Notes

Reaction equation

HRID 2207154 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH2:14]/[CH:15]=[CH:16]/[CH:17]=O)[CH2:7][CH2:6]2.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][NH:27][CH:28]=[CH:29][C:30](=[O:32])[CH3:31]>>[C:30]([C:29]1[CH:15]([CH2:14][N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:9]2=[O:13])[CH:16]=[CH:17][N:27]([CH2:26][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[Cl:19])[CH:28]=1)(=[O:32])[CH3:31]

Participants

3

Reactant 2

HCID 118557992HCID 118557992, compoundHCID 131735879HCID 131735879, compound

Product 1

HCID 118557821HCID 118557821, compound

Procedure

The title compound 41 is prepared according to the procedure reported in step D of Example 8 with aldehyde 44 (113 mg, 0.46 mmol) and enamine 45 (94 mg, 1 equiv) as reactants. (Yield 82.4 mg, 41%).

Sources & evidence

ORD record
ord-c9688f1412d345b1b10b77d6ad9ce65d
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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