HuagongsheHuagongshe Chemistry Print Report · For research reference only
Crotonaldehyde → 6-Methoxy-1-oxo-3,4-dihydroisoquinolin-2-ylpent-2-enal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Crotonaldehyde | HCID 447466 | — |
| Reactant | 2-But-3-enyl-6-methoxy-3,4-dihydroisoquinolin-1-one | HCID 118558012 | — |
| Product | 6-Methoxy-1-oxo-3,4-dihydroisoquinolin-2-ylpent-2-enal | HCID 131735880 | — |
Reaction Steps
The title compound 50 is prepared according to the procedure reported in step C of Example 8 with amide 49 (230.0 mg, 0.99 mmol) and crotonaldehyde (3.98 mmol, 4 equiv) as reactants. Yellow solid. (Yield 0.147 g, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-2871f39f402542ba951000f6496e2a2a |
| Source note | uspto-grants-2016_06 |