HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzylamino)but-3-en-2-one → 2-[(3-acetyl-1-benzyl-4H-pyridin-4-yl)methyl]-6-methoxy-tetralin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzylamino)but-3-en-2-one | HCID 521443 | — |
| Reactant | (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal | HCID 90303875 | — |
| Product | 2-[(3-acetyl-1-benzyl-4H-pyridin-4-yl)methyl]-6-methoxy-tetralin-1-one | HCID 118558050 | — |
Reaction Steps
The title compound 52 is prepared according to the procedure reported in step D of Example 8 with aldehyde 54 (100 mg, 0.41 mmol) and enamine 30 (70 mg, 0.4 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum 4/EtOAc=4:1) afford the title compound 52 as a yellow oil. (Yield 55.0 mg, 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-3316a983497d437799059e4eeda23c09 |
| Source note | uspto-grants-2016_06 |