HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal → 2-[[3-acetyl-1-[(2-fluorophenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal | HCID 90303875 | — |
| Reactant | 4-[(2-Fluorophenyl)methylamino]but-3-en-2-one | HCID 131735881 | — |
| Product | 2-[[3-acetyl-1-[(2-fluorophenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one | HCID 118557974 | — |
Reaction Steps
The title compound 55 is prepared according to the procedure reported in step D of Example 8 with aldehyde 54 (100 mg, 0.41 mmol) and enamine 56 (115 mg, 0.59 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum/EtOAc=2:1) afford the title compound 55 as a yellow solid. (Yield 0.11 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-861e2957fe95447e9187387ff8815b8f |
| Source note | uspto-grants-2016_06 |