HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal → 2-[[3-acetyl-1-(p-tolylmethyl)-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal | HCID 90303875 | — |
| Reactant | 4-(p-Tolylmethylamino)but-3-en-2-one | HCID 90304434 | — |
| Product | 2-[[3-acetyl-1-(p-tolylmethyl)-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one | HCID 118557943 | — |
Reaction Steps
The title compound 57 is prepared according to the procedure reported in step D of Example 8 with aldehyde 54 (100 mg, 0.41 mmol) and enamine 58 (110 mg, 0.57 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum Ether/EtOAc=2:1) afford the title compound 57 as a yellow oil. (Yield 63.0 mg, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5ed5c4b721c84a419df58048b9e252cc |
| Source note | uspto-grants-2016_06 |