3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone → HCID 118557822, compound

HRID 2207186Notes

Reaction equation

HRID 2207186 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[CH2:8][CH2:7][CH2:6]2.[F:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:22]=1[CH:23]=O>>[F:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:22]=1/[CH:23]=[C:8]1/[C:9](=[O:15])[C:10]2[C:5]([CH2:6][CH2:7]/1)=[CH:4][C:3]([O:2][CH3:1])=[C:12]([O:13][CH3:14])[CH:11]=2

Participants

3

Reactant 2

HCID 2668163,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenoneHCID 27630033-Fluoroisonicotinaldehyde

Product 1

HCID 118557822HCID 118557822, compound

Procedure

The title compound 86 was prepared according to the procedure reported in Example 34.2 with 6,7-dimethoxy-1-tetralone (1.65 g, 8 mmol) and 3-fluoro-4-pyridinecarboxaldehyde (1.0 g, 8 mmol) as reactants. White solid. (Yield 2.24 g, 89%).

Sources & evidence

ORD record
ord-1551b071c5dd45648f15de0e81437d15
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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