HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-3-chlorobenzene → 2-[[3-Acetyl-1-[(3-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
| Reactant | 2-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one | HCID 118558014 | — |
| Product | 2-[[3-Acetyl-1-[(3-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide | HCID 118557841 | — |
Reaction Steps
The title compound 122 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 3-chlorobenzyl bromide (39 μL, 0.3 mmol) as reactants. White solid. (Yield 75.0 mg, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-d730c638762145a0b749282d7a91651e |
| Source note | uspto-grants-2016_06 |