alpha-Bromo-2-nitrotoluene → 2-[[3-Acetyl-1-[(2-nitrophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide
Reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[N+:24]([C:27]1[CH:34]=[CH:33][CH:32]=[CH:31][C:28]=1[CH2:29][Br:30])([O-:26])=[O:25]>>[Br-:30].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:29][C:28]2[CH:31]=[CH:32][CH:33]=[CH:34][C:27]=2[N+:24]([O-:26])=[O:25])[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]Participants
3
Procedure
The title compound 125 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 2-nitrobenzyl bromide (73 mg, 0.34 mmol) as reactants. White solid. (Yield 87.1 mg, 82%).
Sources & evidence
- ORD record
- ord-529f44133a9345c19d75d3f846bba9d9
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09376387B2
Reaction notes
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