alpha-Bromo-o-chlorotoluene → 2-[[3-Acetyl-1-[(2-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

HRID 2207216Notes

Reaction equation

HRID 2207216 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[Cl:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27][Br:28]>>[Br-:28].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=2[Cl:24])[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 1185579082-[[3-Acetyl-1-[(2-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

Procedure

The title compound 126 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 2-chlorobenzyl bromide (39 μL, 0.3 mmol) as reactants. White solid. (Yield 72.3 mg, 70%).

Sources & evidence

ORD record
ord-2a2cd3b3cd6545cfa29f5a04185beca2
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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