HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl bromide → 2-[[3-Acetyl-1-[(4-fluorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | 2-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one | HCID 118558014 | — |
| Product | 2-[[3-Acetyl-1-[(4-fluorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide | HCID 118557889 | — |
Reaction Steps
The title compound 129 is prepared according to the procedure reported in Example 38.1 with compound 103 (110 mg, 0.36 mmol) and 4-fluorobenzyl bromide (76 μL, 0.61 mmol) as reactants. White solid. (Yield 149 mg, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-97e7007ac1fb41a895a0f5aacdb0f0dc |
| Source note | uspto-grants-2016_06 |