1-(Bromomethyl)-4-chlorobenzene → HCID 118557818, compound

HRID 2207221Notes

Reaction equation

HRID 2207221 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][Br:30])=[CH:27][CH:26]=1>>[Br-:30].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:29][C:28]2[CH:31]=[CH:32][C:25]([Cl:24])=[CH:26][CH:27]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 118557818HCID 118557818, compound

Procedure

The title compound 131 is prepared according to the procedure reported in Example 38.1 with compound 103 (120 mg, 0.387 mmol) and 4-chlorobenzyl bromide (135.5 mg, 0.66 mmol) as reactants. White solid. (Yield 176.6 mg, 90%).

Sources & evidence

ORD record
ord-38378bd511da47da9d4f44f8940a6bfd
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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