o-Xylyl bromide → HCID 118557975, compound

HRID 2207230Notes

Reaction equation

HRID 2207230 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:22][CH3:23])=[C:16]([O:20][CH3:21])[CH:17]=2)[C:12]1=[O:24])(=[O:3])[CH3:2].[CH3:25][C:26]1[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=1[CH2:28][Br:29]>>[Br-:29].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:25][C:26]2[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=2[CH3:28])[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:22][CH3:23])=[C:16]([O:20][CH3:21])[CH:17]=2)[C:12]1=[O:24])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6992o-Xylyl bromideHCID 90300564HCID 90300564, compound

Product 1

HCID 118557975HCID 118557975, compound

Procedure

The title compound 142 is prepared according to the procedure reported in Example 38.1 with compound 32 (130.1 mg, 0.4 mmol) and 2-methylbenzyl bromide (90 μL, 0.68 mmol) as reactants. White solid. (Yield 130 mg, 63%).

Sources & evidence

ORD record
ord-2ee2ef3f189c4be1a85e603e5394559d
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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