o-Xylyl bromide → HCID 118557956, compound

HRID 2207231Notes

Reaction equation

HRID 2207231 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH:7]([CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[C:22]([NH:24][CH3:25])=[O:23])[CH2:6]2.[CH3:26][C:27]1[CH:34]=[CH:33][CH:32]=[CH:31][C:28]=1[CH2:29][Br:30]>>[Br-:30].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH:7]([CH2:15][C:16]1[CH:21]=[CH:20][N+:19]([CH2:26][C:27]3[CH:34]=[CH:33][CH:32]=[CH:31][C:28]=3[CH3:29])=[CH:18][C:17]=1[C:22]([NH:24][CH3:25])=[O:23])[CH2:6]2

Participants

3

Reactant 2

HCID 6992o-Xylyl bromideHCID 118558004HCID 118558004, compound

Product 1

HCID 118557956HCID 118557956, compound

Procedure

The title compound 143 is prepared according to the procedure reported in Example 38.1 with compound 116 (51.1 mg, 0.15 mmol) and 2-methylbenzyl bromide (40 μL, 0.3 mmol) as reactants. Yellow solid. (Yield 47.5 mg, 71%).

Sources & evidence

ORD record
ord-16533856c4bb4f18b673ff8c764aaf74
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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