1-(Bromomethyl)-3-chlorobenzene → HCID 118558025, compound

HRID 2207232Notes

Reaction equation

HRID 2207232 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:22][CH3:23])=[C:16]([O:20][CH3:21])[CH:17]=2)[C:12]1=[O:24])(=[O:3])[CH3:2].[Cl:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29][Br:30]>>[Br-:30].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:29][C:28]2[CH:31]=[CH:32][CH:33]=[C:26]([Cl:25])[CH:27]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:22][CH3:23])=[C:16]([O:20][CH3:21])[CH:17]=2)[C:12]1=[O:24])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 90300564HCID 90300564, compound

Product 1

HCID 118558025HCID 118558025, compound

Procedure

The title compound 144 is prepared according to the procedure reported in Example 38.1 with compound 32 (95.1 mg, 0.29 mmol) and 3-chlorobenzyl bromide (65 μL, 0.49 mmol) as reactants. White solid. (Yield 108 mg, 70%).

Sources & evidence

ORD record
ord-a4bd622110f14c879666072d16adc4e3
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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