o-Xylyl bromide → HCID 118558040, compound

HRID 2207236Notes

Reaction equation

HRID 2207236 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([CH3:21])=[C:16]([CH3:20])[CH:17]=2)[C:12]1=[O:22])(=[O:3])[CH3:2].[CH3:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][Br:27]>>[Br-:27].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:23][C:24]2[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=2[CH3:26])[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][C:15]([CH3:21])=[C:16]([CH3:20])[CH:17]=2)[C:12]1=[O:22])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6992o-Xylyl bromideHCID 118557874HCID 118557874, compound

Product 1

HCID 118558040HCID 118558040, compound

Procedure

The title compound 152 is prepared according to the procedure reported in Example 38.1 with compound 111 (41.1 mg, 0.14 mmol) and 2-methylbenzyl bromide (32 μL, 0.24 mmol) as reactants. Pale yellow solid. (Yield 66 mg, 97%).

Sources & evidence

ORD record
ord-ae79ea48c12e4cd7bb3a9242211faa7d
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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