Benzyldihydronicotinamide → 2-[[3-acetyl-1-[(4-fluorophenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one

HRID 2207239Notes

Reaction equation

HRID 2207239 reaction equation
[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=2)[C:13]1=[O:24])(=[O:4])[CH3:3].C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=3)[C:13]2=[O:24])[CH:9]=[CH:8][N:7]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH:6]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 95276BenzyldihydronicotinamideHCID 1185578892-[[3-Acetyl-1-[(4-fluorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

Product 1

HCID 1185579452-[[3-acetyl-1-[(4-fluorophenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one

Procedure

The title compound 155 is prepared according to the procedure reported in Example 39.1 with compound 129 (75 mg, 0.15 mmol) and BNAH (32 mg, 1 equiv) as reactants. Yellow solid. (Yield 31.4 mg, 50%).

Sources & evidence

ORD record
ord-2ad9d744d2de4dfdb3436eefc3babc88
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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