HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyldihydronicotinamide → 2-[[3-acetyl-1-[(2-chlorphenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyldihydronicotinamide | HCID 95276 | — |
| Reactant | 2-[[3-Acetyl-1-[(2-chlorophenyl)methyl]pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide | HCID 118557908 | — |
| Product | 2-[[3-acetyl-1-[(2-chlorphenyl)methyl]-4H-pyridin-4-yl]methyl]-6-methoxy-tetralin-1-one | HCID 118558001 | — |
Reaction Steps
The title compound 157 is prepared according to the procedure reported in Example 39.1 with compound 126 (60 mg, 0.12 mmol) and BNAH (25 mg, 1 equiv) as reactants. Yellow solid. (Yield 25 mg, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-cab71ec605794d389460fbcf66435b22 |
| Source note | uspto-grants-2016_06 |