Benzyldihydronicotinamide → HCID 118557917, compound

HRID 2207248Notes

Reaction equation

[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[C:23](=[O:24])[C:22]2[C:14](=[CH:15][C:16]3[O:20][CH2:19][O:18][C:17]=3[CH:21]=2)[CH2:13]1)(=[O:4])[CH3:3].C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[C:23](=[O:24])[C:22]3[C:14](=[CH:15][C:16]4[O:20][CH2:19][O:18][C:17]=4[CH:21]=3)[CH2:13]2)[CH:9]=[CH:8][N:7]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH:6]=1)(=[O:4])[CH3:3]

Participants

Reactant 2

HCID 95276Benzyldihydronicotinamide

HCID 118558043HCID 118558043, compound

Product 1

HCID 118557917HCID 118557917, compound

Procedure

The title compound 165 is prepared according to the procedure reported in Example 39.1 with compound 139 (100 mg, 0.20 mmol) and BNAH (43 mg, 1 equiv) as reactants. Yellow solid. (Yield 32.1 mg, 38%).

Sources & evidence

ORD record: ord-b050b2b5446047e3b9d2c97dc2fbc268
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376387B2

Reaction notes

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