Benzyldihydronicotinamide → HCID 118557961, compound

HRID 2207250Notes

Reaction equation

[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:21])[CH:18]=2)[C:13]1=[O:22])(=[O:4])[CH3:3].C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([Cl:21])[CH:18]=3)[C:13]2=[O:22])[CH:9]=[CH:8][N:7]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH:6]=1)(=[O:4])[CH3:3]

Participants

Reactant 2

HCID 95276Benzyldihydronicotinamide

HCID 118557800HCID 118557800, compound

Product 1

HCID 118557961HCID 118557961, compound

Procedure

The title compound 167 is prepared according to the procedure reported in Example 39.1 with compound 136 (42 mg, 0.08 mmol) and BNAH (19 mg, 1 equiv) as reactants. Yellow solid. (Yield 17.5 mg, 50%).

Sources & evidence

ORD record: ord-3759db38c3cf43b0a22274e7a6e01649
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376387B2

Reaction notes

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