Benzyldihydronicotinamide → HCID 118557839, compound

HRID 2207251Notes

Reaction equation

HRID 2207251 reaction equation
[Br-].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[CH:8]([CH2:16][C:17]1[CH:22]=[CH:21][N+:20]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[CH:19][C:18]=1[C:31]([NH:33][CH3:34])=[O:32])[CH2:7]2.C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[CH:8]([CH2:16][CH:17]1[CH:22]=[CH:21][N:20]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])[CH:19]=[C:18]1[C:31]([NH:33][CH3:34])=[O:32])[CH2:7]2

Participants

3

Reactant 2

HCID 95276BenzyldihydronicotinamideHCID 118557956HCID 118557956, compound

Product 1

HCID 118557839HCID 118557839, compound

Procedure

The title compound 168 is prepared according to the procedure reported in Example 39.1 with compound 143 (89.1 mg, 0.2 mmol) and BNAH (1 equiv) as reactants. Pale yellow solid. (Yield 35.7 mg, 40%).

Sources & evidence

ORD record
ord-25201aa6ed2a4fb994310e1b59a18b8e
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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