Benzyldihydronicotinamide → HCID 118557858, compound

HRID 2207252Notes

Reaction equation

[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][C:16]([O:23][CH3:24])=[C:17]([O:21][CH3:22])[CH:18]=2)[C:13]1=[O:25])(=[O:4])[CH3:3].C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[CH2:20][C:19]3[C:14](=[CH:15][C:16]([O:23][CH3:24])=[C:17]([O:21][CH3:22])[CH:18]=3)[C:13]2=[O:25])[CH:9]=[CH:8][N:7]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[CH:6]=1)(=[O:4])[CH3:3]

Participants

Reactant 2

HCID 95276Benzyldihydronicotinamide

HCID 118557975HCID 118557975, compound

Product 1

HCID 118557858HCID 118557858, compound

Procedure

The title compound 169 is prepared according to the procedure reported in Example 39.1 with compound 142 (7 4.2 mg, 0.15 mmol) and BNAH (35 mg, 1 equiv) as reactants. Yellow solid. (Yield 32.3 mg, 50%).

Sources & evidence

ORD record: ord-33d6574d3c3a4e38ba716f6f2e87882b
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376387B2

Reaction notes

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