HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-phenoxy-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6-phenoxypyridazin-3(2H)-one | HCID 46889305 | — |
| Reactant | 5-Bromo-2-(3-(chloromethyl)phenyl)pyrimidine | HCID 59438047 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-phenoxy-2H-pyridazin-3-one | HCID 58497071 | — |
Reaction Steps
3.3 2.59 g (9.14 mmol) of 5-bromo-2-(3-chloromethylphenyl)pyrimidine and 2.84 g (8.70 mmol) of caesium carbonate are added to a suspension of 1.64 g (8.70 mmol) of 6-phenoxy-2H-pyridazin-3-one in 17.5 ml of DMF, and the mixture is stirred at room temperature for 18 hours. Water is added to the reaction mixture. The precipitate formed is filtered off with suction, washed with water and dried in vacuo, giving 2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-phenoxy-2H-pyridazin-3-one as colourless crystals; ESI 435, 437.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376426B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8d9c167bb9674671bae10d4f73cf5ce8 |
| Source note | uspto-grants-2016_06 |