Cesium carbonate → HCID 73775728, compound

Participants

Reaction Steps

20.0 mg of 4,6-di(furan-3-yl)pyridin-3-ol and 24.9 mg of 3-cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide were dissolved in DMF, and 86.0 mg (3.0 eq) of Cs2CO3(86.0 mg, 3.0 eq) was added thereto. After reacting at room temperature for 2 hours, the resulting mixture was reacted at 60° C. for 16 hours. The solvent was removed by concentrating under reduced pressure. AS work-up with EA/H2O, the ethyl acetate layer was treated with magnesium sulfate, and concentrated under reduced pressure. The residue was separated by PLC (developing solvent, EA:n-Hex=1:4) to obtain 10.1 mg (24% yield) of the title compound.

Provenance & Evidence