HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 73775730, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Reactant | HCID 90100518 | HCID 90100518 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | HCID 73775730 | HCID 73775730 | 28.4% |
Reaction Steps
10 mg of 4-((6-chloro-4-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)oxy)-3-cyano-N-(thiazol-2-yl)benzenesulfonamide was dissolved in DMF/H2O=1:1 (0.46 mL), and 3.2 mg of (2-fluoropyridin-3-yl)boronic acid, 0.8 mg of Pd(PPh3)4 and 7.4 mg of Na2CO3 were added thereto. After reacting with microwave reactor at 120° C. for 5 minutes, DMF was removed by concentrating under reduced pressure. After extracting with EA, the extract was treated with MgSO4 and concentrated under reduced pressure. The residue was separated by PLC (developing solvent, EA) to obtain 3.2 mg (28% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376429B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-0e1bfe03d2b04a2f911e25fe7f49d8dc |
| Source note | uspto-grants-2016_06 |