反应详情

10 mg (0.02 mmol) of 4-((6-chloro-[4,4′-bipyridin]-3-yl)oxy)-3-cyano-N-(thiazol-2-yl)benzenesulfonamide was dissolved in 3 mL of N,N-dimethylformamide, and 5 mg (0.03 mmol) of (2,6-difluoropyridin-3-yl)boronic acid was added thereto, and then 2.4 mg (10 mol %) of Pd(PPh3)4, 6.7 mg (0.6 mmol) of Na2CO3, and 1 mL of H2O were added thereto. After reacting with microwave reactor at 120° C. for 10 minutes, the solvent was removed, and the remaining material was diluted with ethyl acetate and the organic layer was separated, and washed with saturated sodium chloride. The organic layer was collected, dried with magnesium sulfate to remove water, and concentrated under reduced pressure, and the residue was purified by column chromatography (developing solvent, hexane:ethyl acetate=3:1) to obtain 2 mg (19% yield) of the title compound.

1. customthe solvent was removed
2. additionthe remaining material was diluted with ethyl acetate
3. customthe organic layer was separated
4. washwashed with saturated sodium chloride
5. customThe organic layer was collected
6. dry with materialdried with magnesium sulfate
7. customto remove water
8. concentrationconcentrated under reduced pressure
9. customthe residue was purified by column chromatography (developing solvent, hexane:ethyl acetate=3:1)