HCID 90100619, compound → HCID 73775012, compound

Participants

Reaction Steps

10 mg (1.0 eq) of the obtained tert-butyl 4-(4-(5-(4-(N-(tert-butoxycarbonyl)-N-(thiazol-4-yl)sulfamoyl)-2-chloro-5-fluorophenoxy)-2-(3-fluorophenyl)pyridin-4-yl)pyrimidin-2-yl)piperazin-1-carboxylate was dissolved in 0.2 oL dimethylchloride, and 0.2 mL of trifluoroacetic acid was added thereto. The mixture was reacted at room temperature for 2 hours. The solvent was removed by concentrating under reduced pressure. The residue was separated by PLC (developing solvent, dimethylchloride:methanol=15:1) to obtain 2.0 mg of 5-chloro-2-fluoro-4-((6-(3-fluorophenyl)-4-(2-(piperazin-1-yl)pyrimidin-4-yl)pyridin-3-yl)oxy)-N-(thiazol-4-yl)benzenesulfonamide.

Provenance & Evidence