反应详情

2 ml (24.8 mmol) of pyridine and 4.2 ml (49.8 mmol) of 2,4,6-trifluorotriazine were added to a suspension of 5.0 g (24.8 mmol) of 6-chloro-2-ethylamino-nicotinic acid in 125 ml of dichloromethane. The mixture was stirred for 3 hours at ambient temperature and then filtered. The solid was rinsed with 50 ml of dichloromethane and the filtrate was washed twice with 60 ml of ice-cold water. The organic phase was dried over Na2SO4 and the solvent was evaporated off under reduced pressure. 5.01 g of product were obtained in the form of an orange oil which was used without further purification.

1. filtrationfiltered
2. washThe solid was rinsed with 50 ml of dichloromethane
3. washthe filtrate was washed twice with 60 ml of ice-cold water
4. dry with materialThe organic phase was dried over Na2SO4
5. customthe solvent was evaporated off under reduced pressure