HCID 89827399, compound → HCID 117831911, compound

Participants

Reaction Steps

A solution of 16 (50 mg, 0.126 mmol) in toluene (2 ml) was cooled to −1° C., degassed with vacuum and flushed N2. To this solution was charged a precooled (−2 to 0° C.) aqueous NaOH (1N, 1 mL) followed by charged a catalyst 18. The resulted reaction was aged at −1 to 1° C. for several hours until complete conversion. The organic layer was purified with silica gel column chromatography (0 to 10% AcOEt/hexane) to give the desired compound 17 as oil (42 mg, 92% IY, 85% ee, R or S undetermined).

Provenance & Evidence